Senior Director, Scientific Project Lead (Cardio-Renal-Metabolic)

The Role

Generate is seeking a Senior Director,  Scientific  Project Lead,   Cardio-Renal-Metabolic  to lead complex, cross-functional scientific programs from concept and early discovery through preclinical proof-of-concept, contribute to translational and early development strategy, and manage and develop scientific talent.

This role combines formal people management with broad cross-functional leadership across research, platform, translational, development, and portfolio functions. Working closely with functional , business and technical  leaders,  project managers ,  and senior and executive stakeholders, the  Scientific  Project Lead   will bring scientific judgment   in therapeutic discovery , strategic program leadership, and operational rigor to align multidisciplinary teams, guide key decisions, represent programs in governance forums, and contribute to portfolio prioritization.

Here's how you will contribute

• Lead complex programs from concept and early discovery through preclinical proof-of-concept, with accountability for scientific strategy, execution quality, team effectiveness, risk management, and stage-gate readiness.

• Develop and  maintain  integrated program strategies and plans that align scientific  objectives , timelines, and resourcing.

• Set  scientific  program direction,  identify  and advance therapeutic opportunities and target proposals by integrating biology, Generate’s differentiated platform capabilities, internal and external evidence, translational and clinical rationale, and competitive intelligence.

• Facilitate cross-functional discussions, resolve divergent perspectives, make clear recommendations, own key  scientific   decisions within the  project  team structure, and drive  timely  go/no-go recommendations.

• Drive execution across wet  lab , computational,  platform , and translational workstreams, ensuring scientific rigor, reproducibility, strong documentation, and high-quality data packages.

• Develop resource plans and budget assumptions,  anticipate  strategic inflection points, and proactively resolve risks, gaps, and cross-functional dependencies.

• Build effective operating mechanisms for program planning, governance preparation, risk tracking, decision-making, and cross-functional accountability.

• Manage, coach, and develop direct reports through clear  objectives , regular feedback, performance management, and career development; mentor cross-functional team members in partnership with their functional managers.

• Set clear expectations and foster a high-performing  team  culture grounded in scientific rigor, accountability, transparency, urgency, collaboration, and constructive challenge.

The Ideal Candidate will have

• PhD, MD, or MD/PhD in the life sciences or another discipline relevant to therapeutic discovery and development.

• 12+ years of r elevant  experience in biotech, pharma, academia, or a related scientific environment.

• Experience  identifying , evaluating,  and  advancing therapeutic targets and programs in cardio-renal-metabolic diseases  or related areas , including relevant  in vitro and in vivo  preclinical  models  and translational considerations such as biomarkers and PK/PD.

• Demonstrated success advancing complex programs across discovery and translational stages, including stage-gate reviews, prioritization decisions, and early development planning.

• Experience managing and developing scientists or other technical professionals, together with a strong record of leading multidisciplinary teams through influence.

• Strong scientific grounding in biology, experimental design, data interpretation, and synthesis across multiple technical domains.

• A track record  of identifying, evaluating, and advancing novel targets or therapeutic opportunities with strong biological and translational rationale.

• Experience shaping program strategy, influencing senior stakeholders, and driving decisions in matrixed environments without relying solely on direct  line  authority.

• Ability to synthesize complex scientific issues, make sound recommendations with incomplete information, navigate scientific and resource tradeoffs, and communicate clearly in governance settings.

• Strong operational leadership, learning agility, intellectual curiosity, and comfort working in ambiguous and evolving environments, with a practical approach to solving problems and unblocking teams.

Preferred Qualifications

• Experience with protein therapeutics and related modalities, including peptides and conjugate-based approaches.

• Familiarity with computational protein design, machine learning-enabled discovery, or platform-scale biological systems.

• Familiarity with IND-enabling studies and early clinical development.

• Experience working effectively with consultants, CROs, and other external partners.

• Comfort using LLM-enabled tools and emerging agentic workflows to support scientific planning, analysis, and execution.

Who Will Love This Job

• A biomedical scientist who enjoys  identifying  novel targets and turning early ideas into well-defined therapeutic opportunities.

• A scientifically grounded leader energized by complex programs, consequential decisions, and incomplete information.

• An entrepreneurial, hands-on problem solver who thrives at the interface of biology, platform technologies, translational science, and portfolio strategy.

• A matrix leader who builds trust, sets a high bar, and aligns strong cross-functional partners through influence.

• A people leader who enjoys developing talent while building resilient, collaborative, and high-performing teams.

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range