Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)
Description
Peptide Chemist
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Plan and execute solid-phase and solution-phase peptide synthesis (SPPS/LPPS) using automated synthesizers such as Syro and CEM Liberty Blue
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Independently handle peptide synthesis across scales from gram to 1 kg, with troubleshooting abilities
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Purify and characterize peptides using preparative HPLC, analytical HPLC, LC-MS, and MS
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Operate, calibrate, and maintain lab equipment to keep synthesis workflows running smoothly
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Maintain compliance with laboratory safety and SHE (Safety, Health & Environment) standards
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Review relevant literature to inform synthetic strategy and troubleshooting approaches
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Keep accurate, timely experimental records (lab notebooks, batch records, ELN entries as applicable)
High Potent APIs (HPAPI)
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Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.
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Execute chemical reactions, work-ups, purification and related laboratory processes.
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Handle HPAPIs in accordance with applicable safety, containment and handling procedures.
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Maintain accurate laboratory records, experimental data and documentation.
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Support process development, optimization and troubleshooting activities.
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Perform analytical sample preparation and coordinate with analytical teams as required.
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Follow established GMP, EHS and laboratory safety requirements.
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Support investigation and resolution of laboratory/process-related issues.
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Where required, support chemistry activities related to ADC and highly potent payloads.
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Work effectively with cross-functional teams including analytical and other chemistry groups.
Organic Chemist
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Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance
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Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography
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Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations
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Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately
Scaleup Chemist
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Experience in process R&D, scale-up synthesis, and purification from gm to kg scale
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Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities
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Proficient in 1H NMR, HPLC, and LCMS interpretation
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Strong project execution and team collaboration skills
Antibody Drug Conjugation Chemist (ADC)
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Synthesis and purification of complex antibody drug conjugate (ADC) molecules
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Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs
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Synthesis of highly potent drug molecules – payloads
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Purification of complex and large molecules by flash column and HPLC
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Handling various type chemistry with different payloads
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Interpretation and characterisation of higher molecular weight compounds