Executive Medical Director, Global Medical Lead (Pain)
Description
Job Description
General Summary
The Executive Medical Director, Global Medical Lead (GML), Pain is a critical leadership role in Global Medical, responsible for the global medical strategy and impl eme ntation and tracking of global activities for a designated disease area(s) . Key responsibilities include, but are not limited to, disease area specific Integrated Medical Plan development, including the publication plan, global launch strategy and execution, scientific leadership, external medical expert engagement, and strategic alignment with commercial and other cross-functional business partners. This leader will also be critical in leading post-approval evidence generation strategy in the disease area. This leader reports directly to the VP, Global Medical and is a core member of the Global Medical leadership team. They will lead the global medical affairs team for the designated disease area(s ) and represents Medical Affairs in all Global strategic teams with D evelopment and Commercial, including the Disease Strategy Team (DST) to drive cross-functional alignment, anticipate future needs, and contribute to Medical Affairs and Vertex’s long-term success.
Key Duties and Responsibilities
Medical Strategy
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Lead the development, implementation, execution, and communication of the Integrated Medical Plans, including but not limited to medical strategy, global tactical plan, publication , congress and post - approval evidence generation plan , in collaboration with Clinical Development, HEOR, RWE, Medical Writing, and other internal stakeholders across Vertex
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Ensure alignment of medical strategy with organizational objectives by integrating individual and disease area team goals with Vertex and DST priorities, and the goals of cross-functional partners
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Expertly distills insights and actionable outcomes that inform strategy and drive the greatest impact for Medical Affairs
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Establishes and tracks medical KPIs that demonstrate impact on business and patient outcomes.
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Applies structured problem-solving and root cause analysis to identify solutions and make decisions that maximize medical and business impact
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Able to identify what is important and impactful to medical and the wider business , prioritize competing demands a nd communication to key stakeholders
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Accountable for development of the global DA budget, management of funds allocation, and associated tracking to ensure alignment with Medical Affairs priorities and efficient resource allocation
Scientific Excellence
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Serve as product and disease area expert and primary contact point for all gl obal disease area related issues with the external community and internally at Vertex
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Able to lead development of peer reviewed publications, congress presentations and evidence generation to shape clinical practice
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Closely follow medical developments within disease area and disseminate new information to transform clinical trends and emerging data into new plans
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Lead the development of global scientific communications and materials including materials for global led symposia, advisory boards, and training.
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Accountable for medical review of assigned brand related con t ent and global medical content aligned with Vertex SOPs
External Partnerships
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Represent Vertex at scientific and medical forums, including medical education forums, scientific societies, patient advocacy groups, and congresses.
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Accountable for engaging and cultivating relationships with leading global key thought leaders (TL) to gain greater understanding of the disease area, and insights into unmet patient needs
Medical Communication
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Tailors communication to stakeholder needs, building trust and understanding across diverse audiences.
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Deliver external presentations (advisory board meetings, symposia, other medical education meetings) to enhance the medical knowledge of pipeline and marketed products, as required and in accordance with relevant regulations and procedures
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Support disease area training across the company as required
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Responsible for medical interpretation of data (clinical trials, registries, published literature, etc.) for pipeline therapies and marketed medicines
Regional Medical and Cross Functional Collaboration
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Accountable for go to market model and medical partnership in commercialization with global cross-functional colleagues. In absence of regions teams , country go to market mode l remains the responsibility of the GML.
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S upport regional Medical Affairs and Medical Excellence teams from launch through lifecycle via timely delivery of fit-for-purpose training and core materials.
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Responsible for driving alignment on medical content/messaging within the organization to ensure maximal functional and regional input.
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Medical Affairs leader on key global cross-functional product and development strategic focused teams , including DST and relevant sub teams
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Effectively represents and communicates DST priorities to the medical function and proactively communicates and represents medical needs to DST
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Chair the Global Medical Area Team (GMAT) for the disease area and accountable for deliverables
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Provide strategic Medical Affairs leadership on relevant commercial teams: Launch Team, and Global brand teams for product
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Represent Medical Affairs in label discussions
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Support Access, Patient Advocacy, Policy, and Corporate Communications teams with medical/scientific expertise and materials review.
Evidence Generation and Access
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Leads strategy, development and execution of Life Cycle Management in partnership with HEOR , including Integrated Evidence Generation plan in close collaboration with key internal stakeholders
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May act as medical monitor for studies falling under the Medical Affairs scope in collaboration with Clinical Development, Real World Evidence, Health Economics and Outcomes Research, and Clinical Operations
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Lead oversight and management of ISS programs, and in collaboration with Regional Medical leadership, conduct critical scientific and medical review of ISS protocols
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As applicable, lead Managed Access Committee for assets with a Managed Access Program (MAP); may act as a Medical Monitor for MAP
Team/People Management
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Provide strong leadership to dedicated disease area medical team, inspiring and empowering a dedicated medical team , and promoting a culture of continuous development.
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Accountable for the r ecruitment, development, management and coaching the global medical team
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Leverages the capabilities and expertise of the team to ensure successful execution of medical plans
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Identifies and addresses team skill gaps, considering how to accelerate internal talent or attract external to meet needs of a future-ready organization.
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Adheres to formal goal-setting , talent and performance cycles ensuring individual development plans (IDPs) are in place
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Navigates ambiguous or rapidly evolving situations, and coach the team during periods of uncertainty or change.
Compliance and Pharmacovigilance:
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Ensure compliance of medical activities a ccording to global and regional guidelines and in accordance with Vertex Code of Conduct, rules and regulations, company policies, SOPs, GCP and ICH
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Ensure self and othe r medical colleagues have the required skills to identify and report AEs appropriately
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Contribute to managing external communication when significant safety issues arise, with the wellbeing of patients being the ultimate goal
Education and Experience:
- MD, PhD, PharmD or other advanced life sciences degree require
- Typically requires 15 ye