Senior Medical Director, Medical Affairs

About Beeline Medicines:

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully.

Job Summary:

The Senior Medical Director, Medical Affairs is a senior therapeutic and disease area expert who serves as the organization's primary external medical and scientific resource for healthcare providers (HCPs), key medical experts (KMEs), clinical investigators, healthcare plans, hospital formulary decision-makers, and patient advocacy organizations. This role operates at the intersection of scientific leadership and external engagement — building and sustaining trusted peer-level relationships within the I&I community while driving the development and execution of the organization's medical affairs strategy most notably for the Beeline Medicines lead program; an investigational selective, oral, once-daily TLR7/8 inhibitor advancing into pivotal development for systemic and cutaneous lupus erythematosus — and for the broader I&I portfolio. The Senior Medical Director leads scientific exchange, supports evidence generation, shapes medical education and KME engagement programs, and serves as a senior internal scientific authority — providing medical input to clinical development, commercial readiness, market access, and regulatory strategy.  The Senior Medical Director also serves as a medical reviewer and signatory on the promotional and medical review (MLR) committee for all externally facing company materials for health care professionals, advocacy groups and allied health care functions globally, ensuring factual accuracy and compliance with industry codes of conduct and regulations  Reporting to the SVP of Clinical Development and Medical Affairs, this individual brings deep scientific expertise in autoimmune disease, demonstrated KME relationship management, and the strategic leadership presence required to drive the medical affairs function forward in a clinical-stage, resource-efficient biotech environment.

Work Arrangement & Location:

Hybrid - This position follows a hybrid work schedule, requiring a minimum of two (2) days on-site per week — currently designated as Tuesday and Wednesday . Additional on-site days may be required based on business needs, team priorities, or leadership direction.

Essential Duties and Responsibilities:

• Serve as the primary medical and scientific point of contact for KMEs, clinical investigators, HCPs, healthcare plan decision-makers, and patient advocacy groups within the I&I therapeutic area — with a primary focus on lupus (SLE and CLE) across rheumatology, dermatology, and nephrology — building and sustaining trusted, peer-level relationships that advance the organization's scientific and medical objectives. The Senior Medical Director may also support other therapeutic areas as required.

• Define and lead the execution of the medical affairs strategy for the I&I pipeline, including lupus indications — encompassing KME engagement, evidence generation, medical education, advisory board programming, and publication strategy — in alignment with clinical development milestones and corporate goals.

• Lead and conduct peer-to-peer scientific exchange with KMEs, investigators, and HCPs — sharing clinical and emerging data, discussing unmet medical needs, and gathering external insights that inform medical strategy, pipeline positioning, and commercial readiness.

• Monitor and critically assess competitive clinical data and emerging mechanisms to inform differentiation and scientific positioning.

• Partner with Scientific Communications to develop and maintain the core scientific narrative, medical communications platform, and scientific lexicon; including unbranded disease-state and mechanism-of-action education to build external scientific understanding of a novel target ahead of pivotal readouts.

• Lead the design and execution of medical advisory board meetings — identifying and engaging the right scientific experts, developing scientifically rigorous agendas, and ensuring that advisory board insights translate into actionable medical and strategic recommendations.

• Oversee the development and review of medical content — including medical education materials, scientific slide decks, congress abstracts, posters, and manuscripts — ensuring scientific accuracy, regulatory compliance, and strategic alignment across all external communications.

• Partner with Scientific Communications to develop and execute data disclosure and publication plans as executed in accordance with GPP 2022 and ICMJE authorship criteria.

• Lead scientific engagement strategy for major rheumatology congresses, including KME interactions, data communication planning, and insight capture.

• Provide Medical Affairs support for clinical programs, including investigator and site identification, feasibility input, engagement of steering committee members and national coordinating investigators, scientific input to protocol design, and site-facing scientific training in partnership with Clinical Development and Clinical Operations.

• Partner with Field Medical Affairs and MSL teams to ensure accurate, balanced, and up-to-date scientific tools and resources are available and consistently applied in field engagements — participating directly in key field interactions when the scientific complexity or stakeholder importance warrants senior medical presence.

• Provide strategic medical input into data generation initiatives including interventional (phase 3b, 4) and non-interventional trial design (real world evidence approaches, registry studies) to support market authorization of the asset and life cycle management.

• Collaborate with Clinical Development, Biostatistics, Regulatory Affairs, and other departments on the medical interpretation of clinical data, regulatory submissions, payer engagement strategies, and commercial launch planning — serving as a medical affairs voice across all key cross-functional initiatives.

• Perform other duties and responsibilities as assigned

Qualifications:

• Education: Advanced clinical degree (MD or DO) required. Board certification or clinical training in rheumatology, dermatology, nephrology, immunology, or a related specialty strongly preferred. Additional advanced degree (PhD, MPH, or MBA) is a plus.

• Minimum of 5 years clinical and 5 years pharmaceutical/biotech industry experience in medical affairs inclusive of supporting product launches preferred

• Direct experience managing or advising lupus clinical programs strongly preferred.

• Deep scientific expertise in autoimmune disease — specifically lupus (SLE and/or CLE), rheumatology, and/or nephrology — required.

• Established KME network within the lupus, rheumatology, and dermatology communities strongly preferred.

• Experience supporting a registrational or pivotal program through pre-launch medical affairs readiness — including major congress data disclosure, field medical build-out, and compliant pre-approval payer engagement — strongly preferred.

• Deep clinical and scientific expertise in immunology and inflammation — with primary depth in lupus nephritis, SLE, and/or CLE — including command of disease mechanisms, clinical trial landscapes, standard of care evolution, regulatory developme