Director, Field Medical - West

The Opportunity

We’re   looking for a Director of Field Medical to  serve as the regional scientific lead during a pivotal stage of  our  growth. This senior, full-scope Medical Science Liaison role  rests on two  pillars : leading  high-level scientific exchange and key opinion leader relationships across  your  region  and serving  as the field-facing scientific partner to Maze's clinical development programs.  It ’s  a genuine scientific leadership position,  not site support with a scientific veneer .

With MZE829  entering its  pivotal program in 2027 and MZE782 advancing through Phase 2,  your  immediate priority is enabling the clinical programs, so trial and investigator support   carries  real weight from day one.  B ecause Maze is genetics-first,  you’ll   need credibility across  two distinct communities :  nephrology (AMKD, FSGS, CKD) and metabolic disease (PKU) .   Initially ,  an  individual contributor,   you’ll   build  the  region's scientific relationships and support trial execution , then   help recruit, mentor, and eventually lead a regional  MSL team as we grow

The Impact You’ll Have

Scientific Exchange & KOL Engagement

You’ll   be  a  recognized scientific expert and the trusted face of Maze  in your regions .

• Lead  compliant, peer-to-peer scientific exchange with thought leaders, physicians, renal pathologists, and PKU specialists , and build a durable regional KOL  map, including  in a metabolic community where Maze  isn’t  yet known.

• Provide  accurate  scientific education on AMKD, FSGS, CKD, and PKU, including APOL1 biology and SLC6A19 substrate reduction,  and respond to unsolicited medical  inquires .

• Represent   Maze at major congresses (ASN, NKF, and metabolic / PKU societies)  and  support advisory boards ,  scientific meetings , and  patient advocacy  partnerships.

Clinical Development & Investigator Partnerships

The immediate  priority .  You’ll  be  the field-facing scientific partner accountable for site engagement and  scientific barriers affecting  enrollment across  your   region.

• Serve as the  regional   scientific partner  to  Maze's  trials , including HORIZON and the MZE829 ,  and MZE782 , and the single point of contact for investigators and sites.

• S hape site  selection  through feasibility input ,  and support site identification, investigator meetings, and start-up.

• Own the field-side response to enrollment and retention barriers ,  driv ing  compliant scientific solutions with Clinical Operations.

Genetic Testing & Patient Identification

• Support adoption of APOL1 genotyping  and  a dvance genotype-driven patient identification pathways, the mechanism by which eligible patients reach the trials.

• Address  the trust and access barriers facing an AMKD population disproportionately of African ancestry ,  a concrete enrollment lever, not a peripheral consideration.

Medical Insights & Strategic Input

• C apture field insight (treatment patterns, unmet need, evidence gaps, competitive intelligence) on a consistent cadence , and  t ranslate  it  into recommendations that  shape  medical strategy, evidence generation, and launch readiness .    Because Maze is small, these insights land directly with the people who set direction.

Building the Field Medical Organization

• Carry your  assigned territory personally  as  the senior regional scientific leader, and  help recruit,  mentor,  and develop MSLs as  we  scale, growing into regional team leadership over the next 1–2 years.

As a  Director , we also expect  you  to  demonstrate  the following Leadership Competencies:

• Communication  and Influence

• Builds communication channels across Maze for sharing information

• Influences Senior Management decisions through persuasive arguments

• Respectfully addresses differing opinions leading to support of decision

• Teamwork and  Collaboration

• Champions partnerships and connections across Maze

• Proactively addresses issues that could result in breakdown of team relationships

• Spotlights team and individual contributions in public forums

• Execution and Results

• Addresses gaps and leverages strengths to get best results

• Maintains a steadying presence and clarifies priorities during change

• Anticipates and removes barriers that put functional/corporate goals at risk

• Develop Others and Self

• Removes barriers to staff development and empowers them to make their own decisions

• Stays current on industry trends and keeps direct-reports prepared and responsive

What We’re Looking For

What  you’ll  need

• An a dvanced scientific degree (PharmD, PhD, MD, DO, or equivalent).

• a m inimum of 7 years of Medical Affairs, Field Medical, Clinical Development, or related biopharmaceutical experience.

• A d emonstrated  track record  building  KOL  relationships and leading peer-to-peer scientific exchange. This is a core requirement, not a nice-to-have;  if  you’re   strong on trial  logistics  but light on scientific engagement and KOL relationships , this role  isn’t  the right  fit.

• Demonstrated accountability for site engagement and clinical trial enrollment, not solely data presentation at sites.

• Deep scientific fluency and the credibility to hold a peer-level conversation with an academic specialist.

• W illingness to travel  approximately 60 –70% within the assigned region.

What would be great to have

• Nephrology depth with existing relationships in the kidney community, and genuine willingness to build metabolic and PKU fluency.

• Pre-commercial or first-launch biotechnology experience, built without an established field infrastructure.

• Experience with genotype-driven patient identification and diagnostic testing pathways.

• Experience mentoring MSL s or  leading congress  and  or   scientific-platform  initiatives.

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About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $205,000 - $295,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees inc